Restraining and unleashing chromatin remodelers – structural information guides chromatin plasticity
نویسندگان
چکیده
منابع مشابه
Chromatin Remodelers and Their Way of Action
Chromatin is the packaged form of the eukaryotic genome in the cell nucleus, presenting the substrate for all DNA dependent processes. The basic packaging unit of chromatin is the nucleosome core, a nucleoprotein structure consisting of 8 histone proteins and 147 bp of DNA. Two of each H2A and H2B, H3 and H4, form an octameric, disc like particle on which 1.65 turns of DNA is wrapped [1]. Nucle...
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Chromatin remodelers are key players in the regulation of chromatin accessibility and nucleosome positioning on the eukaryotic DNA, thereby essential for all DNA dependent biological processes. Thus, it is not surprising that upon of deregulation of those molecular machines healthy cells can turn into cancerous cells. Even though the remodeling enzymes are very abundant and a multitude of diffe...
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ISWI family chromatin remodelers typically organize nucleosome arrays, while SWI/SNF family remodelers (RSC) typically disorganize and eject nucleosomes, implying an antagonism that is largely unexplored in vivo. Here, we describe two independent genetic screens for rsc suppressors that yielded mutations in the promoter-focused ISW1a complex or mutations in the 'basic patch' of histone H4 (an e...
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iv Dedication and Acknowledgements vi Table of
متن کاملChromatin remodelers, their implication in cancer and therapeutic potential
The chromatin remodeling complexes alter chromatin structures. They remodel nucleosomes in ATP-dependent manner and have essential roles in DNA damage repair, recombination, replication and transcriptional control. Increasing evidences indicate that subunits of chromatin remodelers are mutated and/or deregulated in a number of human cancers, and how they influence the cancer gene expression pro...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2020
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2020.06.008